By Qin Wang
This quantity of present themes in Membranes makes a speciality of Adrenergic Receptor Biology, starting with a evaluation of earlier successes and historic views then additional discussing present normal developments in adrenic receptor stories in a number of contexts. This e-book additionally contains discussions of the function and dating of adrenergic receptors to assorted platforms and illnesses, developing Adrenergic Receptor Biology as a wanted, functional reference for researchers.
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Extra info for Advances in Adrenergic Receptor Biology
1975). Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity. Nature, 254, 440–441. Su, Y. , Harden, T. , & Perkins, J. P. (1979). Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma. cells Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. J Biol Chem, 254, 38–41. Tan, C. , Wilson, M. , MacMillan, L. , Kobilka, B. , & Limbird, L. E. (2002). Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.
2010). , 2011) are targeted at endomembrane locations where they are functional with respect to cellular signaling. Interestingly, subcellular fractionation experiments in adult rat ventricular cardiomyocytes indicated colocalization of bAR with Nup-62, a marker of the nuclear membrane. ). To our surprise, not only were functional b-adrenergic receptors localized to the nuclear membrane but this localization was subtype-specific. , 2006). Interestingly, both receptors were differentially coupled to signaling pathways in isolated nuclei.
Furthermore, the potential for additional therapeutic drugs that target these systems is considerable since currently available drugs target pathways that are controlled by only about 5% of the 800 identified human G protein-coupled receptors (GPCRs, Fredriksson, Lagerstrom, M. , Lundin, L. , 2003). GPCRs regulate the activity of multiple effectors by activating heterotrimeric G proteins with distinct subunit compositions. The majority of drugs that target GPCR signal transduction systems act as either orthosteric agonists, antagonists, or inverse agonists, although allosteric ligands are becoming more important.